The HPLC demonstrated sensitivity and rapidity in the identification and measurement of the hemoglobins and gave precise results.Moreover, it provided measurement of hemoglobin variants, even when they were present in small amounts, providing a diagnosis of hemoglobinopathies.Hb F levels above the normal were observed in 33.3% of the analyzed samples.The presence of increased Hb F can suggest resistance to infection by Plasmodium falciparum, as there have been reports that infected red blood cells interfere in the development of the parasite.
Avaliação de Hb A2 e Hb F em doadores de sangue de região malarígena da Amazônia Oriental brasileira por HPLC Evaluation of Hb A2 and Hb F by HPLC in blood donors from the malaria endemic region of Eastern Amazon of Brazil
The HPLC demonstrated sensitivity and rapidity in the identification and measurement of the hemoglobins and gave precise results.Moreover, it provided measurement of hemoglobin variants, even when they were present in small amounts, providing a diagnosis of hemoglobinopathies.Hb F levels above the normal were observed in 33.3% of the analyzed samples.The presence of increased Hb F can suggest resistance to infection by Plasmodium falciparum, as there have been reports that infected red blood cells interfere in the development of the parasite.